Phenoxy compounds

Medchemexpress LLC MD2-TLR4-IN-1 | 2249801-12-3 | 98.2% | 10 MG

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MD2-TLR4-IN-1 is a myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex antagonist. It inhibits Lipopolysaccharides (LPS)-induced expression of TNF-α and IL-6 in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively. This compound can be utilized for the study of acute lung injury (ALI).

• Exerts anti-inflammatory activity by inhibiting NF-κB in RAW264.7 macrophages.
• Directly binds to the MD2-TLR4 complex and disrupts MD2-TLR4 activation.
• Suppresses NF-κB p65 subunit nuclear levels in LPS-induced macrophages.
• Significantly inhibits macrophage infiltration and ameliorates histopathological changes in lung tissues.
• Effectively reduces airspace inflammation and amends pulmonary lobule tissue structure.
• Decreases LPS-induced myeloperoxidase (MPO) activity and serum TNF-α levels.
• Reduces mRNA levels of TNF-α, IL-6, IL-1β, IL-12, IL-33, and COX-2 in lung tissues.

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Medchemexpress LLC Berotralstat (BCX7353) | 1809010-50-1 | MFCD33023491 | 99.7% | 562.6 g/mol | C30H26F4N6O | 5 MG

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Berotralstat is a selective, orally active plasma kallikrein inhibitor used in research and clinical development, including prophylaxis studies for hereditary angioedema and investigational work on edema and glioblastoma models. This item is provided as a research-grade solid standard (5 mg) intended for analytical, preclinical, and formulation studies, with documented batch-level characterization and supporting analytical data.

• Selective plasma kallikrein inhibitor for HAE and related research
• Supplied as a 5 mg research-grade solid suitable for analytical use
• High HPLC purity (reported ~99.7%) for reliable results
• Documented certificate of analysis and batch data available
• Suitable for biochemical assays, formulation studies, and reference standards

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Medchemexpress LLC (R)-zanubrutinib | 1691249-44-1 | MFCD31567462 | 99.0% | 471.5 g/mol | C27H29N5O3 | 25 MG

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(R)-Zanubrutinib is the R enantiomer of zanubrutinib, a selective inhibitor of Bruton's tyrosine kinase (BTK). It is provided as a high-purity research compound for biochemical assays and preclinical studies focused on BTK signaling and inhibition.

• High purity suitable for biochemical assays.
• Potent BTK inhibition (IC50 11 nM).
• Available in small research pack sizes for preclinical work.
• Useful for target validation and signaling pathway studies.
• Provided with SDS and CAS registry information for traceability.

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Medchemexpress LLC HY-103483 5mg Medchemexpress, MD2-IN-1 CAS:111797-22-9 Purity:>98%

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Medchemexpress, HY-103483 5mg MD2-IN-1 CAS:111797-22-9 MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189  μM for the recombinant human MD2 (rhMD2). Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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Medchemexpress LLC HY-100488 5mg Medchemexpress, Bay 59-3074 CAS:406205-74-1 Purity:>98%

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Medchemexpress, HY-100488 5mg Bay 59-3074 CAS:406205-74-1 Bay 59-3074 is a selective cannabinoid CB 1 /CB 2 receptor partial agonist with K i values of 48.3 and 45.5 nM at human CB 1 and CB 2 receptors, respectively. Bay 59-3074 has analgesic properties [1] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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eMolecules​ 1262129-47-4 | Ambeed | (R)-33-bis(10-phenyl-9-anthracenyl)-11-binaphthyl-22-diyl Hydrogenphosphate | 50mg | 649783118 | A623541 | 852.926 | C60H37O4P

Ambeed | (S)-1-(3-(4-Amino-3-((35-dimethoxyphenyl)ethynyl)-1H-pyrazolo[34-d]pyrimidin-1-yl)pyrrolidin-1-yl)prop-2-en-1-one | 5mg | 534568910 | A773884 | 1448169-71-8 | MFCD29037352 | 418.457 | C22H22N6O3

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